Update on Graft-versus-Host Disease in paediatrics

by | Jul 24, 2025 | Webinars

Update on Graft-versus-Host Disease in paediatrics

This webinar will be on September 8, 2026 (16:00 CET)

Registration

This webinar will focus on current strategies for the prevention and management of Graft-versus-Host Disease (GvHD) in pediatric allogeneic stem cell transplantation. It will cover advances in T-cell depletion techniques, emerging therapies for steroid-refractory GvHD, and the role of biomarkers and immunological monitoring. The session will highlight evolving approaches to reduce GvHD-related complications while preserving immune function and anti-leukemia effects in children.

Speakers: Dr. Marta González, MD, PhD, Pediatric Oncohematology Department. Haematopoietic Transplant Unit. Niño Jesús University Children’s Hospital (Madrid, Spain).

Learning outcomes: after attending the webinar participants will be able to: 

Knowledge:

  • Understand the pathophysiology of acute and chronic GvHD, including age-specific considerations in pediatric patients. 
  • Review the latest evidence-based guidelines for GvHD prophylaxis and treatment. 
  • Identify key differences in GvHD presentation between pediatric and adult populations. 
  • Gain familiarity with emerging therapies such as ruxolitinib, belumosudil, mesenchymal stromal cells, FMT, and photopheresis. 
  • Explore the role of T-cell depletion strategies (ex vivo and in vivo) in GvHD prevention. 

Practical Skills: 

  • Apply risk stratification tools and biomarkers (e.g., ST2, REG3α) to guide early diagnosis and personalized treatment decisions. 
  • Select appropriate immunosuppressive regimens based on transplant type, donor source, and patient risk profile. 
  • Develop individualized management plans for steroid-refractory acute and chronic GvHD. 
  • Implement supportive care measures to prevent infections and minimize long-term complications in pediatric patients. 
  • Interpret clinical trial data and integrate novel therapeutic approaches into clinical practice. 

Professional Development: 

  • Enhance multidisciplinary collaboration across transplant teams, including hematologists, immunologists, nurses, and pharmacists. 
  • Improve communication with families regarding prognosis, treatment options, and long-term follow-up in children affected by GvHD. 
  • Stay current with international protocols, registries, and research networks (e.g., EBMT, PTCTC). 
  • Foster clinical research involvement and contribute to protocol development in pediatric transplant units.